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Model Uncertainty via the Integration of Hormesis and LNT for Cancer Risk Assessment

Edward Calabrese
USA
2015
DOSE RESPONSE

Edward Calabrese, Professor of Toxicology at the University of Massachusetts, Amherst - The comments offered here assess the scientific foundations of 3 petitions (Carol Marcus, Michael Miller, and Mohan Doss) to the Nuclear Regulatory Commission (NRC) proposing a change in the use of the linear non threshold (LNT) for risk assessment to the hormesis dose–response. It will be shown how hormesis could be applied to cancer risk assessment and how this may be used to optimize the health of radiation-exposed workers and the general public.